After a very long wait, very popular free spyware cleaning software Spybot - Search & Destroy has been updated to version 1.5.1, the new version is 100% compatible with windows vista and has a new user interface. 



Here is the official changelog: 
System support
    * Restored Win95 compatibility
    * Improved Wine compatibility
    * Fixed HyperThreading issues
    * Improved 64 bit immunization
    * Create Portable.ini in main folder to use app folder as data folder as well
    * New warnings about missing admin rights on Windows Vista
    * Support for multi-line bookmarks (IE 7 / Vista)
    * New Immunization for Firefox & Mozilla
    * Improved Immunization for Opera
Reports
    * Added version info to bug report
    * Include Errors.log now includes timestamps
    * Improved Windows version display
Misc
    * "Single excludes" now include filenames to be more unique
    * Improved settings retrieval from registry (mixed installations)
    * Fixed .reg import bugs
    * Added support for automated removal of F/Ps from host lists
    * Changed update UserAgent and Referrer
    * Improved (Vista-compatible) support for fast user switching
    * Updater now in separate executable file
    * Vista manifests for assigning required rights to each application
    * Deactivated list of active ports per process for Vista (incompatible)
    * Fixed support for handle list on 64 bit systems
    * Improved disabling/enabling BHOs
    * New special error reporting for beta versions
    * Support for Windows Error Reporting for public versions
    * Fixed update-related crashes on Vista
    * Fixed memory leaks (replaced Indy with Synapse)
    * Vista-compatible MSI installer for those who like/need that
    * Support for alpha tests on services and domains lists
    * Added hundreds of new automated tests of internal functionality for prerelease QA
    * Added TeaTimer hide icon (disabled) registry value in installer
Detection and removal of threats
    * Improved PE detection all over the place
    * New 64 bit detection all over the place
    * Improved file removal methods
    * Added optional custom RecoveryDir setting in Default.ini
    * Automatic guessing of "Download Dir" folders
    * Added support for renaming services before stopping/killing/deleting them
    * Improved plugin support (example: current TCP/IP Plugin)
    * Support for regular expressions nearly all over the SBI interface
    * Much improved logic connections between files, registry and API detections (others would invent a new TLA for that *g*)
    * Speed-ups through improved caches
    * File version checking
    * Authenticode checking
    * Improved archives checking
    * Faster fulltext checking
    * Improved Sys Internals file location algo
    * Improved hosts file location algo
    * Added some more Opera 9 detection schemes
User interface changes
    * Fixed "show more information" panels
    * Implemented workarounds for misarranged buttons (including TeaTimer)
    * Improved support for /allhives in tools section (inactive installation support)
    * Fixed flag shown on shortcut bar after changes
    * Fixed IE proxy import in wizard
    * Changed "use proxy" button to checkbox
    * Improved localization on simple dialogs
    * Added option to add a proxy inside app if running on Win PE
    * Improved localization of list of updates
    * Added Firefox icon on Cookie exclude page
    * Fixed bad keyboard handling on some exclude lists
    * Fixed cookie removal selection problems
    * New confirmation dialog for system restore points
    * Changed default font to Tahoma
    * Red cross (trademarked) replaced with green cross
    * Made "Check" option unavailable during fix
    * Process list now is a bit less eager on tooltips
    * Improved "delay start" dialogs
    * Now displays checksum for each result for better trackback of results
    * Fixed "Ignore Products" column width problems on Vista
    * Improved localization of product descriptions
    * Adjusted wizard for new situation (external updater etc.)
    * Fixed Tools snapshot comparison highlighting
    * Made display of registry changes in results list less confusing
    * Improved SDHelper dialogs and block/allow choices
    * Update date format on info page now localized
    * Displayed app version is now four digits (e.g. 1.5.1.12)
    * (De+)Select all in list of old reports
    * Improved Warning/Confirmation dialog IE plugin
    * Configuration & Information dialog in IE plugin